Non-aneurysmal non-traumatic subarachnoid hemorrhage: think also in acute promyelocytic leukemia.

نویسندگان

  • Wladimir Bocca Vieira de Rezende Pinto
  • Paulo Victor Sgobbi de Souza
  • Adrialdo José Santos
چکیده

A 45-year-old woman presented with sudden severe excruciating headache. Medical history disclosed intermittent fever and weight loss in the past 3 months. No focal neurological deficits were seen. CT scan disclosed diffuse subarachnoid hemorrhage. Cranial CT angiography showed no intracranial aneurysms (Figure). Laboratory evaluation disclosed thrombocytopenia, anemia and abnormalities of white blood cell. Bone marrow biopsy confirmed acute promyelocytic leukemia (APML). Cerebrovascular disease is a frequent neurological complication in oncological patients, generally secondary to coagulopathies related to the neoplasm or drug-induced bleeding1. Brain hemorrhage is most common in acute leukemias, especially in APML, and sometimes represents the presenting syndrome2.

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عنوان ژورنال:
  • Arquivos de neuro-psiquiatria

دوره 73 12  شماره 

صفحات  -

تاریخ انتشار 2015